The Astros, despite finishing 81-81 and having a negative run differential (-32), still managed to win the AL West and are favored in their playoff matchup. They won five of seven regular-season games against Chicago, including three of the last four. afsport.lat
The White Sox, who had at least 100 losses in each of the last three seasons before this year, are the underdogs at +125. Chicago last won a playoff series in 2005, while the Astros have World Series championships in 2017 and 2022.
